Zhang Fengying, Wu Xijiang, Niu Jinming, Kang Xiufeng, Cheng Liya, Lv Yanchun, Wu Meimei
Otorhinolaryngological Department, Wei Fang Traditional Chinese Hospital, Weifang, Shandong Province, China.
Otorhinolaryngological Department, Shouguang Peoples Hospital, Shouguang, Shandong Province, China.
Onco Targets Ther. 2017 Mar 6;10:1433-1440. doi: 10.2147/OTT.S131611. eCollection 2017.
Accumulating data have reported that polymorphism may be related to nasopharyngeal cancer (NPC) and laryngeal cancer (LC). This meta-analysis was performed to investigate the relationship between polymorphism and risks of NPC and LC.
Pubmed, Embase, and China National Knowledge Infrastructure (CNKI) databases were searched for potential articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the relationship of GSTM1 polymorphism with the risks of NPC and LC. >50% or <0.05 indicates significant heterogeneity. When heterogeneity existed, the random-effects model was used to pool data, otherwise, the fixed-effects model was adopted. Publication bias was detected by Begg's funnel plot and Egger's regression. Quality of each study was evaluated by Newcastle-Ottawa Scale.
Thirty-two eligible articles were included. Pooled outcome suggested the significant relationship of null genotype with increased risk of LC (OR =1.28, 95% CI =1.05-1.54). Compared with hospital-based (HB) population, null genotype was also related to increased risk of LC (OR =1.38, 95% CI =1.06-1.80). Positive relationship of null genotype with enhanced risk of NPC was observed (OR =1.43, 95% CI =1.26-1.63). A similar trend was also observed in the subgroup analysis by source of control (population-based [PB]: OR =1.39, 95% CI =1.18-1.63; HB: OR =1.52, 95% CI =1.22-1.89).
null genotype is related to increased risk of NPC and LC.
越来越多的数据报道，基因多态性可能与鼻咽癌（NPC）和喉癌（LC）有关。本荟萃分析旨在研究基因多态性与NPC和LC风险之间的关系。
检索了PubMed、Embase和中国知网（CNKI）数据库以查找潜在文章。采用比值比（OR）和95%置信区间（CI）来评估谷胱甘肽S-转移酶M1（GSTM1）基因多态性与NPC和LC风险之间的关系。I²>50%或P<0.05表示存在显著异质性。当存在异质性时，采用随机效应模型合并数据，否则采用固定效应模型。通过Begg漏斗图和Egger回归检测发表偏倚。采用纽卡斯尔-渥太华量表评估每项研究的质量。
纳入了32篇符合条件的文章。汇总结果表明，纯合缺失基因型与LC风险增加显著相关（OR=1.28，95%CI=1.05-1.54）。与基于医院的（HB）人群相比，纯合缺失基因型也与LC风险增加有关（OR=1.38，95%CI=1.06-1.80）。观察到纯合缺失基因型与NPC风险增加呈正相关（OR=1.43，95%CI=1.26-1.63）。在按对照来源进行的亚组分析中也观察到类似趋势（基于人群的[PB]：OR=1.39，95%CI=1.18-1.63；HB：OR=1.52，95%CI=1.22-1.89）。
纯合缺失基因型与NPC和LC风险增加有关。
