Jahnke V, Strange R, Matthias C, Fryer A A
Hals-Nasen-Ohren-Klinik und Poliklinik des Virchow-Klinikums der Humboldt-Universität zu Berlin.
Laryngorhinootologie. 1995 Nov;74(11):691-4. doi: 10.1055/s-2007-997826.
While cigarette smoking and alcohol consumption have been linked to laryngeal carcinoma, the role of genetic factors in determining individual susceptibility is unknown. We describe the role of allelism at glutathione-S-transferase GSTM1, GSTT1, and cytochrome P 450 CYP2D6 loci in determining individual susceptibility to laryngeal squamous cell carcinoma.
Enzyme genotypes were determined using the polymerase chain reaction in 169 patients suffering T1-T4 laryngeal carcinoma and in 145 controls.
While the frequency of the heterozygote GSTM1 A/B genotype was statistically significantly lower in the cases than controls, the frequency of the GSTT1 null genotype was higher in cases than controls.
These initial data suggest that allelism at GST loci mediates susceptibility to squamous cell carcinoma of the larynx. Thus, GSTM1 A/B appears to be associated with a reduced risk while GSTT1 null confers increased risk. The findings are compatible with the view that genetic predisposition is important in determining risk of this cancer.
虽然吸烟和饮酒与喉癌有关，但遗传因素在决定个体易感性方面的作用尚不清楚。我们描述了谷胱甘肽-S-转移酶GSTM1、GSTT1和细胞色素P 450 CYP2D6基因座的等位基因在决定个体对喉鳞状细胞癌易感性中的作用。
采用聚合酶链反应测定了169例T1-T4期喉癌患者和145例对照者的酶基因型。
病例组杂合子GSTM1 A/B基因型频率在统计学上显著低于对照组，而GSTT1无效基因型频率在病例组高于对照组。
这些初步数据表明，GST基因座的等位基因介导了对喉鳞状细胞癌的易感性。因此，GSTM1 A/B似乎与风险降低有关，而GSTT1无效则增加风险。这些发现与遗传易感性在决定这种癌症风险中很重要的观点一致。
