二氧化硅致巨噬细胞中毒对实验性肺挫伤的影响及其苯并芘治疗

Casley-Smith J R, Eckert P, Földi-Börcsök E, Földi M

Br J Exp Pathol. 1977 Aug;58(4):386-90.

The effect of poisoning the macrophages with silica on the fine structure of pulmonary contusion was studied in rats. It was found that this causes an increase in the concentration of protein in the interstitial tissue and in the air spaces. It also causes a consequent increase in the amount of interstitial oedema. While the benzo-pyrones normally cause a considerable reduction both in the protein concentrations and in the amount of oedema, they do not act in these ways when the macrophages are poisoned. These results imply that the macrophages normally lyse some of the protein and that this effect is considerably enhanced by the action of the benzo-pyrones.

在大鼠中研究了用二氧化硅毒害巨噬细胞对肺挫伤精细结构的影响。发现这会导致间质组织和肺泡腔中蛋白质浓度增加。这也会导致间质水肿量随之增加。虽然苯并芘通常会使蛋白质浓度和水肿量显著降低，但当巨噬细胞被毒害时，它们不会以这些方式起作用。这些结果表明，巨噬细胞通常会裂解一些蛋白质，并且苯并芘的作用会大大增强这种效果。