Burke Brian, Roux Kyle J
Department of Anatomy and Cell Biology, The University of Florida, Gainesville, FL 32610-0235, USA.
Dev Cell. 2009 Nov;17(5):587-97. doi: 10.1016/j.devcel.2009.10.018.
Eukaryotic cells display considerable morphological plasticity linked to their abilities to carry out a myriad of complex functions. Structural rearrangements associated with cellular activities, from yeast mitosis to cell migration in the mammalian central nervous system, often involve relocation of the cell nucleus. Recent studies have provided insight into how nuclear components can be mechanically coupled to the cytoskeleton, providing a more complete understanding of the role of nuclear positioning in both health and disease.
真核细胞表现出与它们执行无数复杂功能的能力相关的显著形态可塑性。从酵母有丝分裂到哺乳动物中枢神经系统中的细胞迁移，与细胞活动相关的结构重排通常涉及细胞核的重新定位。最近的研究深入了解了核成分如何与细胞骨架机械耦合，从而更全面地理解核定位在健康和疾病中的作用。
