Department of Psychiatry, Geriatric Medicine Unit, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
Neuroimmunomodulation. 2010;17(2):126-31. doi: 10.1159/000258696. Epub 2009 Nov 17.
The aim of this case-control study was to investigate the potential role of the A-2518G polymorphism of the gene of monocyte chemoattractant protein 1 (MCP-1, a cytokine playing an important role in innate immunity) in conferring susceptibility to mood disorders. The sample studied included 96 outpatients with DSM-IV-TR diagnosis of major depressive disorder, bipolar disorder I (BD I) or BD II and 161 matched healthy controls. All subjects were genotyped for the A-2518G polymorphism of the MCP-1 gene. Genotypic and allelic associations were explored between patients and controls and across the different diagnostic groups (chi(2) tests). No genotypic (chi(2) = 8.215, d.f. = 6, p = 0.223) or allelic (chi(2) = 5.058, d.f. = 3, p = 0.168) association for the A-2518G polymorphism of SCYA2 was found considering cases and controls. Nevertheless, important correlations were observed when patients were divided into diagnostic subgroups. A significantly higher frequency of the AA genotype (chi(2) = 7.233, d.f. = 2, p = 0.027) and of the A allele (chi(2) = 4.730, d.f. = 1, p = 0.030) was observed in subjects with BD. In addition, independently from diagnosis, a higher number of lifetime suicide attempts was found in subjects with the AA genotype of the A-2518G polymorphism of the MCP-1 gene (F = 3.802, p = 0.026). The present preliminary results, though limited by the relatively small sample, suggest a possible role of the SCYA2 in conferring susceptibility to BD and, if confirmed, may represent a biological discriminative influence between mood disorder subtypes.
这项病例对照研究旨在探究单核细胞趋化蛋白 1（MCP-1）基因 A-2518G 多态性在易患心境障碍中的潜在作用。该研究样本包括 96 名符合 DSM-IV-TR 诊断标准的门诊患者，分别患有重性抑郁障碍、双相障碍 I 型（BD I）或双相障碍 II 型，以及 161 名匹配的健康对照者。所有受试者均对 MCP-1 基因 A-2518G 多态性进行了基因分型。通过卡方检验（chi(2) tests）探索了患者与对照组之间以及不同诊断组之间的基因型和等位基因关联。考虑病例和对照组，未发现 SCYA2 上 A-2518G 多态性的基因型（chi(2) = 8.215，df = 6，p = 0.223）或等位基因（chi(2) = 5.058，df = 3，p = 0.168）存在关联。然而，当将患者分为诊断亚组时，观察到了重要的相关性。BD 患者中 AA 基因型（chi(2) = 7.233，df = 2，p = 0.027）和 A 等位基因（chi(2) = 4.730，df = 1，p = 0.030）的频率显著更高。此外，独立于诊断，MCP-1 基因 A-2518G 多态性 AA 基因型患者的终生自杀尝试次数更多（F = 3.802，p = 0.026）。尽管初步结果受到样本量相对较小的限制，但这些结果提示 SCYA2 可能在易患 BD 方面具有一定作用，如果得到证实，可能代表了心境障碍亚型之间的生物学区分性影响。
