Barbosa Izabela Guimarães, Bauer Moisés Evandro, Machado-Vieira Rodrigo, Teixeira Antonio Lucio
Divisão de Neuropsiquiatria, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Avenida Alfredo Balena, 190 Santa Efigênia, 30130-100 Belo Horizonte, MG, Brazil.
Laboratório de Imunologia do Envelhecimento, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul (PUC-RS), 90610-000 Porto Alegre, RS, Brazil.
Neural Plast. 2014;2014:360481. doi: 10.1155/2014/360481. Epub 2014 Sep 9.
Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a review on the involvement of cytokines in BD. We also discuss the cytokines involvement in the neuroprogression of BD. It has been demonstrated that increased expression of cytokines in the central nervous system in postmortem studies is in line with the elevated circulating levels of proinflammatory cytokines in BD patients. The proinflammatory profile and the immune imbalance in BD might be regarded as potential targets to the development of new therapeutic strategies.
双相情感障碍（BD）是一种严重、慢性且复发性的精神疾病。它与高患病率的医学合并症和认知障碍有关。其神经生物学尚未完全明确，但最近的证据显示出广泛的免疫变化。细胞因子是参与免疫反应调节与协调的蛋白质。我们对细胞因子在双相情感障碍中的作用进行了综述。我们还讨论了细胞因子在双相情感障碍神经进展中的作用。尸检研究表明，中枢神经系统中细胞因子表达的增加与双相情感障碍患者循环中促炎细胞因子水平的升高相一致。双相情感障碍中的促炎特征和免疫失衡可能被视为开发新治疗策略的潜在靶点。
