Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.
Cancer Biol Ther. 2009 Dec;8(24):2398-405. doi: 10.4161/cbt.8.24.10277. Epub 2009 Dec 9.
The purpose of this study was to evaluate the effectiveness of ultrasonographically guided high-intensity focused ultrasound (HIFU) ablation for superficial malignant tumors. HIFU ablation was applied to 38 cases. The diameter of tumors ranged from 1.5-18 cm, including < or =3 cm in seven cases, >3 to < or =5 cm in four cases, >5 to <10 cm in 15 cases, and > or =10 cm in 12 cases. Using imaging techniques, the volume and activity of tumors were observed before and after HIFU ablation, and the effectiveness of HIFU ablation in superficial malignant tumors was evaluated. For tumors < or =5 cm in diameter, HIFU ablation was completely effective in 100% (11/11) of cases; for tumors >5 cm in diameter, HIFU ablation was completely effective in 25.9% (7/27) of cases, partially effective in 14.8% (4/27) of cases, moderately effective in 33.3% (9/27) of cases; the disease remained stable in 14.8% (4/27) of cases and progressed in 11.1% (3/27) of cases. No significant difference was observed in the tumor volumes before (202.6 +/- 230.4 cm(3)) and 6-8 w after HIFU ablation (188.1 +/- 215.8 cm(3)). However, the difference in the active volume before (202.6 +/- 230.4 cm(3)) and after (127.6 +/- 189.7 cm(3)) HIFU ablation was statistically significant. Among 38 the cases, 32 reported painful symptoms, with a pain score of 4.39 +/- 2.36, before the ablation; the values dropped to 0.19 +/- 0.54 after HIFU, and the difference was statistically different. Thus, HIFU is a safe, effective and promising approach for the treatment of superficial malignant tumors.
本研究旨在评估超声引导高强度聚焦超声（HIFU）消融治疗浅表恶性肿瘤的疗效。对 38 例患者进行 HIFU 消融治疗。肿瘤直径 1.5-18cm，其中<或=3cm 7 例，>3-<或=5cm 4 例，>5-<10cm 15 例，>或=10cm 12 例。采用影像学技术观察 HIFU 消融前后肿瘤的体积和活性，评估 HIFU 消融治疗浅表恶性肿瘤的效果。肿瘤直径<或=5cm 者完全有效率为 100%（11/11）；肿瘤直径>5cm 者完全有效率为 25.9%（7/27），部分有效率为 14.8%（4/27），中度有效率为 33.3%（9/27），疾病稳定率为 14.8%（4/27），进展率为 11.1%（3/27）。HIFU 消融前后肿瘤体积差异无统计学意义（202.6+/-230.4cm(3)、188.1+/-215.8cm(3)），但 HIFU 消融前后肿瘤活性体积差异有统计学意义（202.6+/-230.4cm(3)、127.6+/-189.7cm(3)）。38 例患者中有 32 例诉疼痛，术前疼痛评分为 4.39+/-2.36，HIFU 后疼痛评分为 0.19+/-0.54，差异有统计学意义。HIFU 是治疗浅表恶性肿瘤安全、有效、有前途的方法。
