Department of Ophthalmology, University of Gothenburg, Gothenburg, Sweden.
Pediatr Res. 2010 Mar;67(3):325-9. doi: 10.1203/PDR.0b013e3181ca9f43.
The aim of this study was to evaluate the influence of early and later postnatal growth variables on optic disc morphology in children (n = 53) born at gestational age <32 wk. On fundus photographs taken at a median age of 5.4 y, the optic discs were evaluated using digital image analysis and compared with those of a control group (n = 203). The results were analyzed in relation to gestational age, birth weight (BW) SD score (SDS), IGF-1 weight at postmenstrual age 32 wk (SDS), and weight, length, and head circumference (SDS) at follow-up. The preterm children's optic disc and neuronal rim areas were smaller than in the control group. Low BW (SDS) and weight at wk 32 (SDS) were associated with larger area of the optic cup and reduced neuronal rim area. Preterm children with known brain lesions (n = 6) had significantly larger cups than preterm children without known brain lesions. The association found between both low BW and poor early growth and later reduced neuronal tissue of the optic nerve indicate that early weight gain is important for neural development in preterm children.
本研究旨在评估小于 32 孕周出生的儿童（n=53）的早期和晚期出生后生长变量对视盘形态的影响。在中位年龄为 5.4 岁时拍摄的眼底照片上，使用数字图像分析对视盘进行评估，并与对照组（n=203）进行比较。将结果与胎龄、出生体重（BW）标准差评分（SDS）、32 孕周后 IGF-1 体重（SDS）以及随访时的体重、长度和头围（SDS）进行分析。早产儿的视盘和神经节细胞边缘区域小于对照组。低 BW（SDS）和 32 孕周时的体重（SDS）与视杯面积增大和神经节细胞边缘区域减少有关。已知有脑部病变的早产儿（n=6）的视杯明显大于无已知脑部病变的早产儿。低 BW 和早期生长不良与后期视神经神经组织减少之间的关联表明，早产儿的早期体重增加对于神经发育很重要。
