Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
Molecules. 2009 Nov 3;14(11):4414-24. doi: 10.3390/molecules14114414.
This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
本研究调查了暗罗（番荔枝科）的生物活性提取物，其具有抗菌、抗疟和细胞毒性活性。广泛的色谱分离提供了吖啶酮生物碱；onychine（1）和 7-甲氧基onychine（2）以及β-谷甾醇和豆甾醇的混合物。这两种生物碱是首次从 P. debilis 中分离出来的。含有三萜混合物（C7、C8 和 C9）的分离部分对许多细菌菌株表现出最强的抗菌活性，最小抑菌浓度为 64μg/mL。也观察到具有抗疟和细胞毒性活性的部分。研究结果表明，暗罗具有在医学应用中的潜在用途。
