Faculty of Medicine, Department of Dermatology, University of Tokyo, Tokyo, Japan.
J Invest Dermatol. 2010 Apr;130(4):1034-9. doi: 10.1038/jid.2009.349. Epub 2009 Nov 19.
The immunological significance of IL-27 has been reported and discussed in various Th1/Th17-mediated inflammatory diseases. However, its importance in psoriasis is unknown. We investigated pathophysiological roles of IL-27 in psoriasis in this study. Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls, and correlated with disease severity and serum IFN-gamma levels. An immunohistochemical analysis revealed the infiltration of IL-27-secreting cells in the papillary dermis of psoriatic skin lesions but not in skin lesions with atopic dermatitis or normal skin. Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1alpha and CCL20. These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis.
IL-27 的免疫学意义已在各种 Th1/Th17 介导的炎症性疾病中被报道和讨论。然而，其在银屑病中的重要性尚不清楚。在本研究中，我们研究了 IL-27 在银屑病中的病理生理作用。银屑病患者的血清 IL-27 水平明显高于健康对照组，且与疾病严重程度和血清 IFN-γ水平相关。免疫组织化学分析显示，IL-27 分泌细胞浸润在银屑病皮损的乳头真皮中，但不在特应性皮炎皮损或正常皮肤中。此外，IL-27 单独可极大地诱导体外 CXCL9、CXCL10 和 CXCL11 的产生和信号转导和转录激活因子 1 的酪氨酸磷酸化，而抑制肿瘤坏死因子-α诱导的 IL-1α 和 CCL20 的产生。这些结果表明，IL-27 可能促进银屑病的发病，同时可能减轻该疾病中炎症的扩大。我们的结果提示 IL-27 可能对银屑病具有潜在的治疗作用。
