Puelles Luis
Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia and CIBERER-U736, Murcia, Spain.
Int J Dev Biol. 2009;53(8-10):1145-60. doi: 10.1387/ijdb.082589lp.
The contributions of Cajal to Neuroembryology are glossed with the help of a selection of images extracted from Cajals (1929) own synthesis of his neuroembryological output, laying emphasis on the persisting relevance and unsurpassed quality of many individual achievements and milestones he delivered on neurohistogenesis, practically throughout his career. Cajals theoretical background as regards embryology, morphology, comparative neuroanatomy and evolution is sketched at the beginning. The body of the review is divided into sections covering spinal cord, cerebellum, cortex, retina, sensory organs and muscular terminals, and astroglia. The deep and common-sensical conceptual analysis of neural histological variation during development performed by Cajal is highlighted at several points, as well as the places where he advanced genial conjectures that reached far forward in time, placing him still at the front of present day neuroembryological thinking. Some errors committed by Cajal are also commented upon. At one point (the retina), some of the present authors own observations with a Golgi method variant are presented, as they complement observations that Cajal left incomplete because of technical problems. The major neuroembryological works of Cajals pupil Jorge F.Tello are mentioned at the end.
借助从 Cajal（1929 年）对其神经胚胎学研究成果的自身总结中选取的一系列图像，阐述了 Cajal 对神经胚胎学的贡献，重点强调了他在神经组织发生学方面诸多个人成就和里程碑的持久相关性及卓越品质，这些成就几乎贯穿了他的整个职业生涯。开篇简述了 Cajal 在胚胎学、形态学、比较神经解剖学和进化方面的理论背景。综述主体分为多个部分，涵盖脊髓、小脑、皮层、视网膜、感觉器官和肌肉终末以及星形胶质细胞。文中多次强调了 Cajal 对发育过程中神经组织学变化所做的深刻且符合常识的概念分析，以及他提出的那些超前且极具创见的推测，这些推测使他至今仍处于当今神经胚胎学思想的前沿。同时也对 Cajal 所犯的一些错误进行了评论。在关于视网膜的部分，展示了本文作者之一运用改良高尔基方法所做的一些观察结果，因为这些结果补充了 Cajal 因技术问题而未完成的观察。文末提及了 Cajal 的学生 Jorge F. Tello 的主要神经胚胎学著作。
