PtCl(2)-catalyzed cycloisomerization of 1,6-enynes for the synthesis of substituted bicyclo[3.1.0]hexanes.

The mild and efficient PtCl(2)-catalyzed cycloisomerization of 1,6-enynes containing a heteroatom substituent at the propargylic position is described. The reactions led to the formation of 1-alkenylbicyclo[3.1.0]hexanes in good to excellent yields or 2-(bicyclo[3.1.0]hex-1-yl)acetaldehydes in moderate yields.