金催化的含环丙叉基 1,5-烯炔的对映选择性扩环环化反应。
Gold-catalyzed enantioselective ring-expanding cycloisomerization of cyclopropylidene bearing 1,5-enynes.
机构信息
Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
出版信息
Org Lett. 2014 Apr 18;16(8):2272-5. doi: 10.1021/ol5007955. Epub 2014 Mar 31.
Abstract
An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products.
摘要
一种含有环丙基部分的 1,5-烯炔的对映选择性环扩张环化反应已经被开发出来。这种方法为双环[4.2.0]辛烷提供了一种新的合成途径，双环[4.2.0]辛烷是许多生物活性天然产物中存在的结构基序。
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