Worcester Heath D, Vasef Mohammad A
Department of Pathology, University of New Mexico, Albuquerque, NM 87102, USA.
Pediatr Dev Pathol. 2010 Jan-Feb;13(1):50-4. doi: 10.2350/09-03-621-CR.1.
Intensified chemotherapy is one of the strategies currently used in the treatment of children with metastatic Ewing sarcoma. However, the increasing dose intensity has not significantly improved the event-free survival. We report a patient who initially presented with localized Ewing sarcoma and later developed metastatic disease that required dose-intensified chemotherapy. The patient's Ewing sarcoma remained refractory to treatment despite continuous intensified chemotherapy and was complicated by a therapy-related acute myeloid leukemia with 11q23 abnormality. Examination of bone marrow at the last clinical follow up demonstrated both acute myeloid leukemia and residual metastatic Ewing sarcoma.
强化化疗是目前用于治疗转移性尤因肉瘤患儿的策略之一。然而，剂量强度的增加并未显著改善无事件生存期。我们报告了一名患者，该患者最初表现为局限性尤因肉瘤，后来发展为转移性疾病，需要进行剂量强化化疗。尽管持续强化化疗，该患者的尤因肉瘤仍对治疗耐药，并并发了伴有11q23异常的治疗相关急性髓系白血病。在最后一次临床随访时对骨髓进行检查发现既有急性髓系白血病又有残留的转移性尤因肉瘤。
