Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA.
Anticancer Agents Med Chem. 2009 Dec;9(10):1105-13. doi: 10.2174/187152009789735053.
Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.
肿瘤干细胞是存在于肿瘤中的亚群细胞，负责肿瘤的发生。这些细胞具有独特的生物学特性，包括自我更新和分化能力。此外，人们认为这些细胞对常规化疗更具抵抗力，因此是导致患者复发的原因。我们将讨论前列腺癌干细胞的鉴定、它们的独特特性以及如何针对这些细胞进行更有效的治疗。
