Kourtis Athena P, Bansil Pooja, Kahn Henry S, Posner Samuel F, Jamieson Denise J
Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Curr HIV Res. 2009 Sep;7(5):481-6. doi: 10.2174/157016209789346228.
The prevalence of diabetes in the United States is rising. As HIV-infected people live longer, they become more susceptible to chronic diseases such as diabetes. Additionally, some antiretroviral agents have been linked to impaired glucose tolerance and increased diabetes risk. To estimate the burden and trends of diabetes among hospitalized HIV-infected persons in the United States, we used data from the 1994-2004 Nationwide Inpatient Sample, a nationally representative survey of inpatient hospitalizations. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for demographic and hospital characteristics using logistic regression. Between 1994 and 2004, the rate of hospitalizations with a diabetes code per 100 hospitalizations increased from 3.9 to 8.4 (2.2 fold) among HIV-infected persons. Among HIV-uninfected people, the corresponding rate increased from 12.8 to 17.7 (1.4 fold). Since 1998, the mean age of HIV-infected hospitalized people with a diabetes diagnosis rose from 45 to 66 years and became similar to that of HIV-uninfected people. Compared to 1994-1996, in 2002-2004 the probability of hospitalizations with diabetes increased among both HIV-infected and HIV-uninfected persons (OR, 1.92, 95% CI, 1.79-2.05 and OR, 1.38, 95% CI, 1.36-1.40, respectively). Given the increasing prevalence of diabetes in hospitalized HIV-infected persons, it will be important to monitor the trends closely in addition to the effects of different types of antiretroviral regimens, in order to optimize comprehensive long-term care of HIV-infected persons.
美国糖尿病的患病率正在上升。随着感染艾滋病毒的人寿命延长，他们更容易患上糖尿病等慢性病。此外，一些抗逆转录病毒药物与糖耐量受损和糖尿病风险增加有关。为了估计美国住院的感染艾滋病毒者中糖尿病的负担和趋势，我们使用了1994 - 2004年全国住院患者样本的数据，这是一项对住院治疗具有全国代表性的调查。使用逻辑回归对人口统计学和医院特征进行调整后得出优势比（OR）和95%置信区间（CI）。1994年至2004年期间，每100次住院中伴有糖尿病诊断编码的住院率在感染艾滋病毒者中从3.9升至8.4（增长了2.2倍）。在未感染艾滋病毒的人群中，相应的比率从12.8升至17.7（增长了1.4倍）。自1998年以来，被诊断患有糖尿病的住院艾滋病毒感染者的平均年龄从45岁升至66岁，与未感染艾滋病毒者的平均年龄相近。与1994 - 1996年相比,在2002 - 2004年，感染艾滋病毒者和未感染艾滋病毒者中因糖尿病住院的概率均有所增加（优势比分别为1.92，95%置信区间为1.79 - 2.05；优势比为1.38，95%置信区间为1..36 - 1.40）。鉴于住院的感染艾滋病毒者中糖尿病患病率不断上升，除了监测不同类型抗逆转录病毒治疗方案的效果外，密切监测趋势对于优化艾滋病毒感染者的长期综合护理非常重要。
