Michel R T, Vering A, Schnürch H G, Schopohl B
Abteilung für Gynäkologie und gynäkologische Onkologie, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main.
Strahlenther Onkol. 1991 Jan;167(1):31-4.
The influence of radiotherapy on tumor growth and hormone receptor concentration (estrogen-, progesteron-receptor) in xenotransplanted human breast cancer is observed. Tumor growth significantly is delayed under therapy during the first 35 days after radiation. Renewed growth follows after that time. After the first days of treatment the ER and PR concentration decreases considerably and finally reaches 40% respectively 30% of the pretreatment level for a period of approximately 35 days after the end of radiotherapy. In general radiation therapy seems to affect the PR stronger than the ER. After this period ER and PR levels increase again with the regrowing tumor. The results point out that radiotherapy reduces the concentration of ER and PR in human breast cancer. Therefore the assay of steroid receptors in human breast cancer after radiation therapy is useful in predicting hormone dependency and prognosis only when receptor concentrations are positive.
观察了放射治疗对异种移植的人类乳腺癌肿瘤生长及激素受体浓度（雌激素受体、孕激素受体）的影响。在放疗后的前35天内，治疗期间肿瘤生长显著延迟。此后肿瘤重新生长。治疗开始后的最初几天，雌激素受体（ER）和孕激素受体（PR）浓度大幅下降，放疗结束后约35天内，最终分别降至预处理水平的40%和30%。总体而言，放射治疗对PR的影响似乎比对ER更强。在此期间之后，随着肿瘤重新生长，ER和PR水平再次升高。结果表明，放射治疗可降低人类乳腺癌中ER和PR的浓度。因此，仅当受体浓度为阳性时，放射治疗后人乳腺癌中类固醇受体的检测才有助于预测激素依赖性和预后。
