Maria-Aggeliki Kalogeridi S, Nikolaos Kelekis L, Kyrias George M, Vassilis Kouloulias E
Radiotherapy Department, Attikon University Hospital, Medical School of Athens, Rimini 1 Haidari, 15341 Athens, Greece.
Recent Pat Inflamm Allergy Drug Discov. 2009 Nov;3(3):195-200. doi: 10.2174/187221309789257432.
Although pelvic radiotherapy, either alone or combined with chemotherapy, has proved to be successful in the treatment of patients with rectal, gynecological and urologic cancer, it is not devoid of side effects. Among patients receiving pelvic radiotherapy more than 70% develop acute inflammatory changes causing gastrointestinal symptoms during treatment. The most frequently reported symptom related to radiation-induced intestinal mucositis is diarrhea. Among nutritional interventions used to manage radiation-induced diarrhoea, probiotics has gained popularity. This term describes organisms and substances that improve microbial balance in the intestines. Although encouraging results have been obtained in clinical trials, the potential of oral probiotics to manage gastrointestinal symptoms needs further research. The article also outlines recent patents related to probiotics therapy to reduce radiation induced mocositis.
尽管盆腔放疗，无论是单独使用还是与化疗联合使用，已被证明在治疗直肠癌、妇科癌和泌尿癌患者方面是成功的，但它并非没有副作用。在接受盆腔放疗的患者中，超过70%会在治疗期间出现引起胃肠道症状的急性炎症变化。与放射性肠粘膜炎相关的最常报告症状是腹泻。在用于管理放射性腹泻的营养干预措施中，益生菌越来越受欢迎。这个术语描述了改善肠道微生物平衡的生物体和物质。尽管在临床试验中取得了令人鼓舞的结果，但口服益生菌管理胃肠道症状的潜力仍需进一步研究。本文还概述了与益生菌疗法相关的最新专利，以减少放射性粘膜炎。
