Minervini Giuseppe, Franco Rocco, Marrapodi Maria Maddalena, Fiorillo Luca, Badnjević Almir, Cervino Gabriele, Cicciù Marco
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy.
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00100 Rome, Italy.
Pharmaceuticals (Basel). 2023 Apr 27;16(5):654. doi: 10.3390/ph16050654.
The inflammatory injury of the mucous membranes lining the digestive tract, from the mouth to the anus, is called mucositis. One of the intriguing and compelling new therapeutic modalities that has emerged in recent decades due to advances in our understanding of this condition's pathophysiology is probiotics. The purpose of this meta-analysis is to evaluate the efficiency of probiotics in the treatment of chemotherapy-induced mucositis for head and neck malignancies; a literature search was performed on PubMed, Lilacs, and Web of Science, and articles published from 2000 to 31 January 2023 were considered, according to the keywords entered. The term "Probiotics" was combined with "oral mucositis" using the Boolean connector AND; at the end of the research, 189 studies were identified from the search on the three engines. Only three were used to draw up the present systematic study and metanalysis; this meta-analysis showed that the treatment of mucositis with probiotics is an effective method, and the analysis of the results of these studies showed that the use of probiotics promoted a decrease in the severity of mucositis symptoms.
从口腔到肛门的消化道黏膜的炎性损伤称为黏膜炎。由于我们对这种疾病病理生理学的理解取得了进展，近几十年来出现的一种有趣且引人注目的新治疗方法是益生菌。这项荟萃分析的目的是评估益生菌在治疗头颈部恶性肿瘤化疗引起的黏膜炎中的疗效；根据输入的关键词，在PubMed、Lilacs和Web of Science上进行了文献检索，并考虑了2000年至2023年1月31日发表的文章。使用布尔连接词AND将“益生菌”一词与“口腔黏膜炎”相结合；在研究结束时，从对这三个引擎的搜索中确定了189项研究。只有三项被用于撰写本系统研究和荟萃分析；这项荟萃分析表明，用益生菌治疗黏膜炎是一种有效的方法，对这些研究结果的分析表明，使用益生菌可促进黏膜炎症状严重程度的降低。
