School of Public Health, Faculty of Medicine, Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Clin Transplant. 2010 Sep-Oct;24(5):660-8. doi: 10.1111/j.1399-0012.2009.01163.x.
In solid organ transplantation (TX), perceived health status (PHS) is a relevant patient-reported outcome. For patients on TX waiting lists, PHS information is limited. The aim of this study was therefore to compare PHS of heart, liver, lung, and renal TX candidates.
We used a cross-sectional descriptive design, including consecutive heart, liver, lung and renal TX candidates listed at a university hospital in Belgium. PHS was evaluated using the generic EuroQoL instrument, assessing patients' perceptions of their general PHS, and evaluating the health-related domains of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Data were analyzed using multivariable ordinal logistic regression.
The study included 314 TX candidates: 29 heart, 75 liver, 67 lung, and 143 renal. Analyses controlling for possible PHS-impacting variables (age, gender, marital status, education, comorbidities) yielded significantly disparate results between the four candidate groups. Renal candidates reported best PHS, followed by liver candidates, whereas heart and lung candidates, whose score differences were not significant, had worst PHS.
The EQ-5D seems to be a valuable tool to identify differences in health-related problems in the four different organ candidate groups. The results can be used to create intervention programs focusing on effective clinical management for these patients pre- and post-transplant.
在实体器官移植（TX）中，感知健康状况（PHS）是一个相关的患者报告结果。对于等待 TX 的患者，PHS 信息有限。因此，本研究的目的是比较心脏、肝脏、肺和肾脏 TX 候选者的 PHS。
我们使用了横断面描述性设计，包括比利时一所大学医院的连续心脏、肝脏、肺和肾脏 TX 候选者。使用通用的欧洲生活质量量表（EuroQoL）评估 PHS，评估患者对一般 PHS 的感知，并评估与健康相关的移动性、自我护理、日常活动、疼痛/不适和焦虑/抑郁领域。使用多变量有序逻辑回归分析数据。
本研究纳入了 314 名 TX 候选者：29 名心脏，75 名肝脏，67 名肺和 143 名肾脏。对可能影响 PHS 的变量（年龄、性别、婚姻状况、教育程度、合并症）进行分析后，四个候选者组之间的结果存在显著差异。肾脏候选者报告的 PHS 最佳，其次是肝脏候选者，而心脏和肺候选者的 PHS 最差，两者之间的差异无统计学意义。
EQ-5D 似乎是一种有价值的工具，可以识别四个不同器官候选者群体在健康相关问题上的差异。这些结果可用于制定干预计划，重点关注这些患者在移植前后的有效临床管理。
