Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
J Heart Lung Transplant. 2013 May;32(5):525-32. doi: 10.1016/j.healun.2013.01.1046.
The burden of post-traumatic stress disorder (PTSD) symptoms may be associated with worse outcomes after transplantation. Little is known about the prevalence and correlates of PTSD symptoms in lung transplant recipients.
We conducted a cross-sectional study of lung transplant recipients between April 2008 and February 2010 at a single center. The PTSD Checklist was used to determine the burden of PTSD symptomatology (total score) and percent of subjects with a provisional PTSD diagnosis (validated algorithms). We assessed the relationship between PTSD symptom burden and patient characteristics with multivariable logistic modeling.
We enrolled 210 subjects (response rate 91%). Most patients were female (50%), and Caucasian (89%). The median age was 59 (interquartile range [IQR] 48 to 63) years and the median time between transplant and follow-up was 2.4 (IQR 0.7 to 5.3) years. Clinically significant PTSD symptomatology was observed in 12.6% (8.4% to 17.9%) of subjects. Subjects were more likely to endorse symptoms of re-experiencing (29.5%) and arousal (33.8%) than avoidant symptoms (18.4%). Multivariable linear regression showed higher PTSD symptom scores among recipients who were: younger (p < 0.001); without private insurance (p = 0.001); exposed to trauma (p < 0.001); or diagnosed with bronchiolitis obliterans syndrome (p = 0.005).
Overall prevalence of PTSD (12.6%) in our study was two times higher than the general population. Patient characteristics found to be associated with an increased burden of PTSD symptoms may be useful to consider in future interventions designed to reduce this comorbidity.
创伤后应激障碍（PTSD）症状的负担可能与移植后更差的结果有关。对于肺移植受者 PTSD 症状的患病率和相关性知之甚少。
我们在 2008 年 4 月至 2010 年 2 月在一家中心进行了一项肺移植受者的横断面研究。使用 PTSD 检查表来确定 PTSD 症状负担（总分）和有暂定 PTSD 诊断的受试者比例（经过验证的算法）。我们使用多变量逻辑建模评估 PTSD 症状负担与患者特征之间的关系。
我们纳入了 210 名受试者（应答率为 91%）。大多数患者为女性（50%）和白种人（89%）。中位年龄为 59 岁（四分位距 [IQR] 48 至 63 岁），移植后随访时间中位数为 2.4 年（IQR 0.7 至 5.3 年）。观察到 12.6%（8.4%至 17.9%）的受试者存在明显的 PTSD 症状。与回避症状（18.4%）相比，受试者更有可能出现再体验（29.5%）和觉醒（33.8%）症状。多变量线性回归显示，以下患者 PTSD 症状评分更高：年龄较小（p < 0.001）；无私人保险（p = 0.001）；暴露于创伤（p < 0.001）；或诊断为闭塞性细支气管炎综合征（p = 0.005）。
在我们的研究中，PTSD 的总体患病率（12.6%）是一般人群的两倍。与 PTSD 症状负担增加相关的患者特征可能有助于考虑未来旨在减少这种合并症的干预措施。
