Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Eur Acad Dermatol Venereol. 2010 Jun;24(6):685-91. doi: 10.1111/j.1468-3083.2009.03489.x. Epub 2009 Nov 17.
Angioedema without urticaria can be caused by drugs. The purpose of our study was to assess the prevalence and clinical features of patients with drug-induced angioedema without urticaria.
This study retrospectively reviewed case records at Siriraj Hospital, between January 2007 and December 2008. Patients aged at least 15 years were included.
The prevalence of drug-induced angioedema without urticaria among patients with adverse drug reactions was 2.3%/year. Non-steroidal anti-inflammatory drugs (NSAID) were the most common cause (50%), followed by antibiotics (20%). The commonest NSAID which induced angioedema were ibuprofen and diclofenac. The common sites were periorbital area (67.3%) and lips (27.6%). The median duration of suspected drug therapy before the development of angioedema was 1 day with the range of 10 min to 23 days.
Non-steroidal anti-inflammatory drugs and antibiotics were the most common drugs causing angioedema without urticaria. The duration of onset ranged from minutes to days. After stopping the suspected drugs, symptoms disappeared within 2-5 days in most patients.
无荨麻疹的血管性水肿可由药物引起。本研究旨在评估伴有药物引起的无荨麻疹血管性水肿患者的患病率和临床特征。
本研究回顾性分析了 2007 年 1 月至 2008 年 12 月期间 Siriraj 医院的病例记录。纳入年龄至少 15 岁的患者。
药物不良反应患者中无荨麻疹性血管性水肿的患病率为 2.3%/年。非甾体抗炎药（NSAID）最常见（50%），其次是抗生素（20%）。引起血管性水肿最常见的 NSAID 是布洛芬和双氯芬酸。常见的发病部位是眶周区域（67.3%）和嘴唇（27.6%）。发生血管性水肿前可疑药物治疗的中位持续时间为 1 天，范围为 10 分钟至 23 天。
非甾体抗炎药和抗生素是最常见引起无荨麻疹性血管性水肿的药物。发病时间从数分钟到数天不等。大多数患者停用可疑药物后，症状在 2-5 天内消失。
