Internal Medicine, OhioHealth Riverside Methodist Hospital, Columbus, Ohio, USA.
Internal Medicine, OhioHealth Riverside Methodist Hospital, Columbus, Ohio, USA
BMJ Case Rep. 2023 Sep 22;16(9):e255446. doi: 10.1136/bcr-2023-255446.
Angioedema is potentially life-threating swelling of integument and mucosa that has multiple potential aetiologies with varying mechanisms. Drug-induced angioedema is often easily correlated with the offending agent and can be prevented with discontinuation of the medication. Many medications have now been implicated in drug-induced angioedema but the two most common are ACE inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs). This case highlights severe angioedema secondary to celecoxib and reviews varying aetiologies of angioedema and NSAID hypersensitivity reactions.
血管性水肿是一种潜在危及生命的皮肤和黏膜肿胀，其具有多种潜在病因和不同的发病机制。药物诱导的血管性水肿通常与致病药物容易相关，并且可以通过停止使用药物来预防。许多药物已被牵连到药物诱导的血管性水肿中，但最常见的两种是血管紧张素转换酶抑制剂（ACE 抑制剂）和非甾体抗炎药（NSAIDs）。本病例强调了塞来昔布引起的严重血管性水肿，并回顾了血管性水肿和 NSAID 过敏反应的不同病因。
