Ferro M A
Huddersfield Royal Infirmary, West Yorkshire, England.
Urol Clin North Am. 1991 Feb;18(1):139-43.
The patient presenting with severe bone pain after primary hormonal therapy, with vertebral collapse, or with uremia resulting from ureteric obstruction should be considered for intravenous stilbestrol diphosphate therapy. The urologist can expect early marked improvement in the patients' mobility and pain, with a reduction in analgesic requirements, from a single 7-day course of treatment. In addition, the drug is inexpensive and free of the side effects commonly associated with cytotoxic therapy. Accurate monitoring of the response is possible with serum prostate-specific antigen measurements, which also enable further therapy to be planned efficiently.
对于在接受初始激素治疗后出现严重骨痛、椎体塌陷或因输尿管梗阻导致尿毒症的患者，应考虑给予静脉注射己烯雌酚二磷酸酯治疗。泌尿科医生可以预期，经过一个为期7天的疗程治疗，患者的活动能力和疼痛会早期显著改善，镇痛药物的需求会减少。此外，该药物价格低廉，且没有细胞毒性疗法常见的副作用。通过检测血清前列腺特异性抗原可以准确监测治疗反应，这也有助于高效地规划进一步的治疗。
