Gudziak M R, Smith A Y
Department of Surgery, University of New Mexico School of Medicine, Albuquerque 87131.
West J Med. 1994 Apr;160(4):351-9.
Adenocarcinoma of the prostate is the most common malignant neoplasm occurring in men. About half of patients present with metastatic disease. The mainstay of the treatment of stage D cancer of the prostate is hormonal therapy. Bilateral simple orchiectomy remains the gold standard with which other therapies must be compared. Luteinizing hormone-releasing hormone analogues and antiandrogens are now most commonly used but are costly. Initiating hormonal therapy immediately on diagnosing metastatic disease appears to have some advantage over delaying therapy until a patient is symptomatic. Total androgen blockade also appears to be beneficial in terms of survival but at high cost.
前列腺腺癌是男性中最常见的恶性肿瘤。约一半的患者出现转移性疾病。前列腺D期癌症治疗的主要方法是激素疗法。双侧单纯睾丸切除术仍是其他疗法必须与之比较的金标准。促黄体生成素释放激素类似物和抗雄激素药物目前最为常用，但成本高昂。在诊断出转移性疾病时立即开始激素治疗似乎比等到患者出现症状后再延迟治疗更具优势。就生存率而言，全雄激素阻断似乎也有益，但成本高昂。
