School of Biology, University of Nottingham, Nottingham NG7 2RD, UK.
Parasitology. 2010 Feb;137(2):311-20. doi: 10.1017/S0031182009991028. Epub 2009 Nov 19.
A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.
CBA 和 SWR 亲本品系的 F2 和 F6/7 杂交系的比较为 Heligmosomoides bakeri 抗性的几个先前未检测到的数量性状基因座（QTL）提供了强有力的证据。在第 5 号（Hbnr9 和 Hbnr10）、第 8 号（Hbnr11）和第 11 号（Hbnr13 和 Hbnr14）染色体上检测到 5 个影响第 6 周平均粪便卵计数和/或蠕虫负荷的 QTL，在第 4 周和第 6 周的粪便卵计数中有 3 个 QTL 位于第 5 号（Hbnr9）和第 11 号（Hbnr13 和 Hbnr14）染色体上。两个位于第 8 号（Hbnr11）和第 11 号（Hbnr13）染色体上的黏膜肥大细胞蛋白酶 1（MCPT1）反应的 QTL，两个位于第 5 号（Hbnr10）和第 8 号（Hbnr11）染色体上的成虫蠕虫 IgG1 抗体反应的 QTL，两个位于第 5 号（Hbnr9）和第 11 号（Hbnr13）染色体上的第 6 周 PCV 的 QTL，以及两个位于第 8 号（Hbnr12）和第 11 号（Hbnr15）染色体上的粒状反应的 QTL。我们的数据强调，对 H. bakeri 的抗性是多基因控制的，由 QTL 区域内的基因调节，这些基因具有复杂的层次关系。
