吸血节肢动物唾液蛋白的结构与机制。
Structure and mechanism in salivary proteins from blood-feeding arthropods.
机构信息
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2E-32B Twinbrook 3 Bldg, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.
出版信息
Toxicon. 2010 Dec 15;56(7):1120-9. doi: 10.1016/j.toxicon.2009.11.002. Epub 2009 Nov 26.
Abstract
The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed.
摘要
吸血节肢动物的唾液中含有丰富的配体结合蛋白混合物，这些蛋白的作用是抑制宿主的止血和炎症反应。由于吸血现象已经进化了很多次，不同的分类群利用完全不同的蛋白家族来执行相似的任务。对其中一些蛋白进行的结构研究揭示了它们用于执行功能的新颖而复杂的生物学机制。本文综述了这些结构和机制研究的结果。
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