Behavioural Science Institute, Radboud University Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands.
Appetite. 2010 Apr;54(2):255-61. doi: 10.1016/j.appet.2009.11.006. Epub 2009 Nov 17.
The present study addresses the emergence of emotional eating in adolescence in relation to maternal or paternal psychological control. A reduction of food intake is considered the biological natural response to distress, therefore we tested whether the a-typical stress response of emotional eating develops in interaction with genetic vulnerability. Carrying the A1 allele of the dopamine D2 receptor (DRD2) gene Taq1A polymorphism (rs1800497) is associated with reduced dopamine D2 receptor availability in the brain. We hypothesized that carrying this allele would confer risk for the development of emotional eating, particularly so in adolescents with adverse rearing experiences. Participants were 279 Dutch adolescents (average age of 13.4) that participated in a prospective study with a four-year follow-up. We found a moderator effect of DRD2 genotype on the relation between both maternal and paternal psychological control and increases in emotional eating in both sexes. Adolescents showed only an increase in emotional eating in relation to high psychological control if they carried at least one DRD2 A1 allele. This study is the first to show that the relationship between adverse rearing experiences and emotional eating might be dependent on genetic make-up.
本研究探讨了青少年情绪性进食的出现与母亲或父亲心理控制之间的关系。减少食物摄入被认为是对痛苦的生物自然反应，因此我们测试了情绪性进食的非典型应激反应是否会与遗传易感性相互作用而发展。携带多巴胺 D2 受体（DRD2）基因 Taq1A 多态性（rs1800497）的 A1 等位基因与大脑中多巴胺 D2 受体的可用性降低有关。我们假设携带该等位基因将增加情绪性进食的风险，尤其是在有不良养育经历的青少年中。参与者是 279 名荷兰青少年（平均年龄为 13.4 岁），他们参加了一项为期四年的前瞻性研究。我们发现，DRD2 基因型对母亲和父亲心理控制与男女情绪性进食增加之间的关系有调节作用。如果青少年携带至少一个 DRD2 A1 等位基因，他们仅会因高心理控制而增加情绪性进食。这项研究首次表明，不良养育经历与情绪性进食之间的关系可能取决于遗传构成。
