Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Mol Psychiatry. 2010 Jul;15(7):727-35. doi: 10.1038/mp.2009.4. Epub 2009 Feb 24.
Association studies investigating the link between the dopamine D2 receptor gene (DRD2) and alcohol (mis)use have shown inconsistent results. This may be due to lack of attention for environmental factors. High levels of parental rule-setting are associated with lower levels of adolescent alcohol use and delay of initiation of drinking. We tested whether DRD2 TaqI A (rs1800497) genotype interacts with alcohol-specific parenting practices in predicting the uptake of regular adolescent alcohol use. Non-regular drinkers were selected from a Dutch, nationwide sample of 428 adolescents (mean age 13.4 years at baseline) and participated in a prospective, community-based study with three annual waves. Parental rule-setting was directly and inversely related to adolescent alcohol use over time. For DRD2 genotype no significant main effect was found. DRD2 genotype interacted with parental rule-setting on adolescent alcohol use over time: adolescents, with parents highly permissive toward alcohol consumption and carrying a genotype with the DRD2 A1 (rs1800497T) allele, used significantly more alcohol over time than adolescents without these characteristics. The DRD2 genotype may pose an increased risk for alcohol use and abuse, depending on the presence of environmental risk factors, such as alcohol-specific parenting.
探讨多巴胺 D2 受体基因（DRD2）与酒精（滥用）之间关联的关联研究得出的结果不一致。这可能是由于缺乏对环境因素的关注。高水平的父母规则制定与青少年饮酒水平较低和饮酒开始时间延迟有关。我们测试了 DRD2 TaqI A（rs1800497）基因型是否与特定于酒精的育儿实践相互作用，以预测定期青少年饮酒的采用。从荷兰全国范围内的 428 名青少年（基线时平均年龄为 13.4 岁）中选择非定期饮酒者，并参加了一项具有三个年度波次的前瞻性、基于社区的研究。父母规则制定与青少年饮酒之间存在直接和间接的时间关系。对于 DRD2 基因型，未发现显著的主要作用。DRD2 基因型与父母规则制定对青少年饮酒时间的相互作用：具有高度宽容酒精消费的父母的基因型并携带 DRD2 A1（rs1800497T）等位基因的青少年，随着时间的推移，饮酒量明显多于没有这些特征的青少年。DRD2 基因型可能会增加酒精使用和滥用的风险，具体取决于环境风险因素的存在，例如特定于酒精的育儿实践。
