University of Toronto, Factor-Inwentash Faculty of Social Work, Centre for Applied Social Research, Ontario, Canada.
Vaccine. 2010 Jan 22;28(4):958-64. doi: 10.1016/j.vaccine.2009.10.142. Epub 2009 Nov 17.
Thailand, with the highest number of volunteers to have participated in preventive HIV-1 vaccine trials globally, may be an early adopter of HIV vaccines. We conducted a mixed methods investigation, including 30 in-depth interviews and a venue-based survey. We used a structured questionnaire including conjoint analysis and a fractional factorial experimental design to assess preventive HIV vaccine acceptability and risk compensation among 255 high-risk men who have sex with men (MSM) and transgenders (mean age=26.6 years). HIV vaccine acceptability ranged from 31.6 to 73.8 on a 100-point scale; mean=58.3 (SD=17.1). Vaccine-induced seropositivity (VISP) had the greatest impact on acceptability, followed by efficacy, side effects, duration of protection, out-of-pocket cost and social saturation. Over one-third (34.6%) reported intentions to increase post-vaccination risk behaviors in response to a highly efficacious HIV vaccine. Social and structural interventions to promote HIV vaccine uptake as a prosocial behavior, provide accessible assays to detect VISP, and subsidize vaccine costs, and support for uptake of partially efficacious vaccines in the context of combination prevention, will facilitate HIV vaccine dissemination in Thailand.
泰国是全球参与预防 HIV-1 疫苗试验志愿者人数最多的国家，可能会成为 HIV 疫苗的早期采用者。我们进行了一项混合方法调查，包括 30 次深入访谈和基于场所的调查。我们使用了包括联合分析和分数阶实验设计的结构化问卷，对 255 名高风险男男性行为者和跨性别者（平均年龄 26.6 岁）进行了预防 HIV 疫苗可接受性和风险补偿评估。HIV 疫苗可接受性在 100 分制上的范围为 31.6 至 73.8；平均值=58.3（SD=17.1）。疫苗诱导的血清阳性（VISP）对可接受性的影响最大，其次是疗效、副作用、保护持续时间、自付费用和社会饱和度。超过三分之一（34.6%）的人报告说，他们打算在接种高度有效的 HIV 疫苗后增加接种后的风险行为。在促进 HIV 疫苗接种作为一种亲社会行为、提供可获得的检测 VISP 的检测方法、补贴疫苗费用，以及在组合预防的背景下支持部分有效的疫苗接种方面，社会和结构干预措施将有助于 HIV 疫苗在泰国的传播。
