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分子碘促进新型吡唑并[3,4-d]嘧啶衍生物的合成及其作为潜在抗菌剂的研究。

Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents.

机构信息

Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Vakilabad Blvd 91775-1436 Mashhad, Iran.

出版信息

Eur J Med Chem. 2010 Feb;45(2):647-50. doi: 10.1016/j.ejmech.2009.10.051. Epub 2009 Nov 6.

DOI:10.1016/j.ejmech.2009.10.051
PMID:19926175
Abstract

Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.

摘要

5-氨基-1-(2,4-二硝基苯基)-1H-4-吡唑甲酰胺与芳香醛的碘环化反应一步合成了一系列新的吡唑并[3,4-d]嘧啶衍生物，并对其抗菌活性进行了评价，结果与参考药物链霉素相当。

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