Imaging Sciences Department, Division of Clinical Sciences, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Early Hum Dev. 2009 Dec;85(12):779-83. doi: 10.1016/j.earlhumdev.2009.10.007. Epub 2009 Nov 17.
Very low birth weight (VLBW) infants (weight <1500 g) are increasingly cared for without prolonged periods of positive pressure ventilation (PPV).
To develop a system for 3.0 T magnetic resonance (MR) image acquisition from VLBW infants who are not receiving PPV, and to test the clinical stability of a consecutive cohort of such infants.
Seventy VLBW infants whose median weight at image acquisition was 940 g (590-1490) underwent brain MR imaging with the developed care system as participants in research. Twenty infants (29%) received nasal continuous positive airway pressure (nCPAP), 28 (40%) received supplemental oxygen by nasal cannulae, and 22 (31%) breathed spontaneously in air during the MR examination.
There were no significant adverse events. Seventy-six percent had none or transient self-correcting oxygen desaturations. Desaturations that required interruption of the scan for assessment were less common among infants receiving nCPAP (2/20) or breathing spontaneously in air (2/22), compared with those receiving nasal cannulae oxygen (13/28), p=0.003. Sixty-four (91%) infants had an axillary temperature > or =36 degrees C at completion of the scan (lowest 35.7 degrees C), There was no relationship between weight (p=0.167) or use of nCPAP (p=0.453) and axillary temperature <36 degrees C. No infant became hyperthermic.
VLBW infants who do not require ventilation by endotracheal tube can be imaged successfully and safely at 3.0 T, including those receiving nCPAP from a customised system.
极低出生体重（VLBW）婴儿（体重<1500 克）越来越不需要长时间的正压通气（PPV）。
为不需要气管内插管通气的 VLBW 婴儿开发一种 3.0T 磁共振（MR）图像采集系统，并对接受该系统的连续队列婴儿进行临床稳定性测试。
70 名 VLBW 婴儿（中位数体重为 940 克（590-1490））作为研究对象，接受开发的护理系统进行脑 MR 成像。20 名婴儿（29%）接受鼻持续气道正压通气（nCPAP），28 名（40%）接受经鼻导管补充氧气，22 名（31%）在 MR 检查期间自主呼吸空气。
无重大不良事件。76%的婴儿无或仅有短暂的自行纠正性氧饱和度下降。与接受经鼻导管吸氧的婴儿（13/28）相比，接受 nCPAP 或自主呼吸空气的婴儿（2/20，2/22）中需要中断扫描进行评估的低氧血症较少，p=0.003。64 名（91%）婴儿扫描完成时腋温≥36°C（最低 35.7°C）。体重（p=0.167）或使用 nCPAP（p=0.453）与腋温<36°C 之间无关系。无婴儿出现发热。
不需要经气管内插管通气的 VLBW 婴儿可以在 3.0T 成功且安全地进行成像，包括使用定制系统接受 nCPAP 的婴儿。
