Ogura Y, Takanashi T, Ishigooka H, Ogino N
Department of Ophthalmology, Kyoto University, Japan.
Am J Ophthalmol. 1991 Feb 15;111(2):179-83. doi: 10.1016/s0002-9394(14)72256-1.
We measured the amount of autofluorescence in the lens to evaluate quantitatively lens changes after vitrectomy. Thirteen phakic patients, ranging in age from 12 to 75 years, were studied after unilateral vitrectomy, with a follow-up period of more than two years (range, 26 to 55 months). Autofluorescence in the lens was measured at the center along the ocular axis by fluorophotometry. Lens autofluorescence in the eyes that underwent vitrectomy was significantly higher than in the contralateral eyes that were not operated on (P = .0003). The increase of autofluorescence was correlated significantly with the age at time of vitrectomy (P = .0008). There was no correlation between the increase in autofluorescence and the length of postoperative follow-up or the use of air during vitrectomy. Based on these results, we believe that oxidation of lens proteins intraoperatively may be one of the causes of development of nuclear cataract after vitrectomy.
我们测量了晶状体中的自发荧光量，以定量评估玻璃体切除术后晶状体的变化。对13例年龄在12至75岁之间的有晶状体眼患者进行了单侧玻璃体切除术后研究，随访期超过两年（范围为26至55个月）。通过荧光光度法沿眼轴在晶状体中心测量自发荧光。接受玻璃体切除术的眼睛中的晶状体自发荧光明显高于未手术的对侧眼睛（P = .0003）。自发荧光的增加与玻璃体切除术时的年龄显著相关（P = .0008）。自发荧光的增加与术后随访时间或玻璃体切除术中空气的使用之间没有相关性。基于这些结果，我们认为术中晶状体蛋白的氧化可能是玻璃体切除术后核性白内障形成的原因之一。
