Hester R B, Farris B K
Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma College of Medicine, Oklahoma City.
Am J Ophthalmol. 1991 Feb 15;111(2):215-20. doi: 10.1016/s0002-9394(14)72262-7.
We treated seven patients with incapacitating vertigo elicited by walking down a grocery store aisle or driving a car. Results of neurologic, neuro-ophthalmic, and neuroradiologic examinations were normal. Episodic vertigo secondary to an abnormal oculovestibular response was diagnosed. Each patient was given a trial of 250 to 500 mg of acetazolamide daily. Symptoms resolved completely in four patients, two patients had near resolution of symptoms, and one patient had no relief. Carbonic anhydrase activity has been demonstrated in the inner ear, and acetazolamide has been shown to affect the ion balance of the inner ear fluids.
我们治疗了7例因在杂货店过道行走或开车而引发失能性眩晕的患者。神经学、神经眼科和神经放射学检查结果均正常。诊断为继发于异常眼前庭反应的发作性眩晕。每位患者都接受了每日250至500毫克乙酰唑胺的试验性治疗。4例患者症状完全缓解，2例患者症状接近缓解，1例患者无缓解。内耳已证实有碳酸酐酶活性，且已表明乙酰唑胺会影响内耳液的离子平衡。
