Zhao Xue-yan, Yang Yue-jin, Zhang Jian, Kang Lian-ming, Wei Bing-qi, Gao Xiao-jin, Lü Rong, Zhang Chun-ling
Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Jun;37(6):486-90.
To observe the correlation of plasma amino-terminal pro-A-, B- and C-type natriuretic peptide (NT-proANP, NT-proBNP and NT-proCNP) levels with New York Heart Association (NYHA) functional class and echocardiographic derived parameters of cardiac function in heart failure patients.
Data of NYHA grade, echocardiographic derived parameters of cardiac function, plasma levels of NT-proANP, NT-proBNP and NT-proCNP (measured by enzyme immunoassay method) were obtained in 112 heart failure patients and 44 normal control subjects. The correlation analysis was made between NT-proANP, NT-proBNP, NT-proCNP and NYHA functional class, left atrium diameter (LAD), left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF), respectively.
The plasma concentrations of NT-proANP, NT-proBNP and NT-proCNP in heart failure patients were significantly higher than in control group (all P<0.05). Correlation analysis revealed a strong correlation between NT-proANP and NT-proBNP (r = 0.790, P = 0.000) and a weak correlation between NT-proCNP and NT-proBNP (r = 0.278, P = 0.003) as well as between NT-proCNP and NT-proANP (r = 0.236, P = 0.012) in heart failure patients. Univariant analysis showed that NT-proANP and NT-proBNP were positively correlated to LAD, LVEDD and negatively correlated to LVEF (all P<0.05) while there was no significant correlation between NT-proCNP and echocardiographic derived parameters of cardiac function in heart failure patients. Multivariate stepwise regression analysis including age, gender, NYHA classification, LAD, LVEDD and LVEF revealed that NYHA classification, LVEF, LAD and age were independent predictors of NT-proANP; while NYHA classification, LVEF and age were independent predictors of NT-proBNP while there was no association among these factors and NT-proCNP.
In heart failure patients, the plasma concentration of NT-proANP, NT-proBNP and NT-proCNP were significantly increased and NT-proANP, NT-proBNP but not NT-proCNP were significantly correlated to NYHA classification and echocardiographic derived parameters of cardiac function.
观察心力衰竭患者血浆氨基末端前 A 型、B 型和 C 型利钠肽（NT-proANP、NT-proBNP 和 NT-proCNP）水平与纽约心脏协会（NYHA）心功能分级及超声心动图测定的心脏功能参数之间的相关性。
获取 112 例心力衰竭患者和 44 例正常对照者的 NYHA 分级、超声心动图测定的心脏功能参数、血浆 NT-proANP、NT-proBNP 和 NT-proCNP 水平（采用酶免疫分析法测定）。分别对 NT-proANP、NT-proBNP、NT-proCNP 与 NYHA 心功能分级、左心房内径（LAD）、左心室舒张末期内径（LVEDD）和左心室射血分数（LVEF）进行相关性分析。
心力衰竭患者血浆 NT-proANP、NT-proBNP 和 NT-proCNP 浓度显著高于对照组（均 P<0.05）。相关性分析显示，心力衰竭患者中 NT-proANP 与 NT-proBNP 之间存在强相关性（r = 0.790，P = 0.000），NT-proCNP 与 NT-proBNP 之间以及 NT-proCNP 与 NT-proANP 之间存在弱相关性（r = 0.278，P = 0.003；r = 0.236，P = 0.012）。单因素分析表明，NT-proANP 和 NT-proBNP 与 LAD、LVEDD 呈正相关，与 LVEF 呈负相关（均 P<0.05），而心力衰竭患者中 NT-proCNP 与超声心动图测定的心脏功能参数之间无显著相关性。多因素逐步回归分析纳入年龄、性别、NYHA 分级、LAD、LVEDD 和 LVEF 后显示，NYHA 分级、LVEF、LAD 和年龄是 NT-proANP 的独立预测因素；NYHA 分级、LVEF 和年龄是 NT-proBNP 的独立预测因素，而这些因素与 NT-proCNP 之间无关联。
在心力衰竭患者中，血浆 NT-proANP、NT-proBNP 和 NT-proCNP 浓度显著升高，且 NT-proANP、NT-proBNP 与 NYHA 分级及超声心动图测定的心脏功能参数显著相关，而 NT-proCNP 与上述指标无显著相关性。
