Losin Elizabeth A Reynolds, Rivera Susan M, O'Hare Elizabeth D, Sowell Elizabeth R, Pinter Joseph D
University of California, Los Angeles, CA, USA.
Am J Intellect Dev Disabil. 2009 Sep;114(5):369-80. doi: 10.1352/1944-7558-114.5.369.
Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward > backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech > rest and backward speech > rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions.
唐氏综合征的特征是在言语和语言方面存在极其严重的损伤，但对于这些缺陷的神经基础却知之甚少。我们比较了9名患有唐氏综合征的年轻成年人与9名年龄大致匹配的发育正常的对照组在被动听故事过程中的功能磁共振成像（fMRI）激活模式。在正向>反向言语的情况下，发育正常的组在经典的语言接受区域（颞上回和颞中回）比唐氏综合征组表现出更强的激活；在正向言语>静息和反向言语>静息两种情况下，唐氏综合征组在扣带回、顶叶上下小叶和楔前叶表现出更强的激活。唐氏综合征组在语言（正向言语）和非语言（反向言语）条件下的激活模式几乎没有差异。
