Hartman N, Leong G B, Glynn S M, Wilkins J N, Jarvik M E
Department of Psychiatry and the Biobehavioral Sciences, University of California, Los Angeles.
Am J Psychiatry. 1991 Mar;148(3):374-5. doi: 10.1176/ajp.148.3.374.
The authors used a double-blind crossover design to observe the effect of transdermally administered nicotine on the smoking behavior of 13 psychiatric patients who were not trying to stop smoking. The patients smoked significantly fewer cigarettes while receiving nicotine than while receiving placebo. These data suggest that transdermally administered nicotine can be a useful adjunct in treating nicotine-addicted psychiatric patients in a non-smoking environment.
作者采用双盲交叉设计，观察经皮给予尼古丁对13名无意戒烟的精神病患者吸烟行为的影响。与接受安慰剂时相比，患者在接受尼古丁时吸烟量显著减少。这些数据表明，在非吸烟环境中，经皮给予尼古丁可能是治疗尼古丁成瘾精神病患者的一种有用辅助手段。
