Seccia A, Salgarello M
Catholic University of the Sacred Heart, Department of Plastic Surgery, Rome, Italy.
Angiology. 1991 Jan;42(1):23-9. doi: 10.1177/000331979104200104.
The authors discuss the indications for hydroxypolyethoxydodecan in the sclerosing treatment of angiomas, with particular reference to cavernous, venous, and evolutive angiomas (ie, immature angiomas that fail to involute by eight to ten months). Moreover, the sclerosing agent may be employed, in connection with embolization and subsequent surgery, in arteriovenous angiomas with a relevant cutaneous-subcutaneous development. The authors have successfully used the "interstitial" sclerosing technique, according to Andrews' method. This technique involves interstitial injections to obtain the sclerosis of the thin threads of fibrous tissue stroma between the blood vessels. The sclerosing therapy may cause the complete regression of "low flow" angiomas or, at least, a partial reduction that simplifies the ensuing surgical excision. In the case of partial regression of the angioma obtained with the sclerosing therapy, the surgery of the remaining angioma causes a lesser degree of bleeding (especially in areas that do not particularly lend themselves to surgical exploration, ie, the oral cavity); an increased reliability in the radicality of the intervention (due also to the reduced size of the lesion); and better results from an aesthetic-functional point of view.
作者讨论了羟基聚乙氧基十二烷在血管瘤硬化治疗中的适应证，特别提及海绵状、静脉性和进行性血管瘤（即8至10个月未能自行消退的未成熟血管瘤）。此外，对于有明显皮肤 - 皮下发展的动静脉血管瘤，硬化剂可与栓塞及后续手术联合使用。作者已根据安德鲁斯的方法成功运用“间质”硬化技术。该技术包括间质注射，以使血管间纤维组织基质的细丝发生硬化。硬化治疗可使“低流量”血管瘤完全消退，或至少部分缩小，从而简化后续手术切除。在通过硬化治疗使血管瘤部分消退的情况下，对剩余血管瘤进行手术时出血程度较轻（尤其是在不太适合手术探查的区域，如口腔）；手术根治的可靠性增加（这也归因于病变尺寸减小）；从美学 - 功能角度来看效果更好。
