Kawamura K, Sakata N, Takebayashi S
Second Department of Pathology, School of Medicine, Fukuoka University, Japan.
Angiology. 1991 Jan;42(1):35-43. doi: 10.1177/000331979104200106.
Perivascular innervation in cerebral arteries from 28 human fetuses at twelve to twenty-eight weeks' gestational age was studied histochemically. Neuropeptide Y (NPY)- and vasoactive intestinal polypeptide (VIP)- containing nerve fibers were densely distributed along with adrenergic and cholinergic nerve fibers in the major pial arteries at the base of the brain, an area that forms the circle of Willis, and in the lenticulostriate arteries. In contrast, distribution was sparse in the cortical circumflex branches of the middle cerebral artery, as compared with findings in the lenticulostriate artery of the same diameter. Densely distributed perivascular nerve fibers in the lenticulostriate arteries may play an important role in the pathogenesis of intracerebral hemorrhage.
采用组织化学方法研究了28例孕龄12至28周的人类胎儿脑动脉的血管周围神经支配情况。在构成Willis环的脑底部主要软脑膜动脉以及豆纹动脉中，含神经肽Y（NPY）和血管活性肠肽（VIP）的神经纤维与肾上腺素能和胆碱能神经纤维一起密集分布。相比之下，与相同直径的豆纹动脉相比，大脑中动脉皮质旋支中的分布较为稀疏。豆纹动脉中密集分布的血管周围神经纤维可能在脑出血的发病机制中起重要作用。
