自发性高血压大鼠脑动脉的血管周围神经支配——一项免疫组织化学研究。

Perivascular innervation of the cerebral arteries in spontaneously hypertensive rats--an immunohistochemical study.

作者信息

Kawamura K, Takebayashi S

机构信息

Second Department of Pathology, School of Medicine, Fukuoka University, Japan.

出版信息

Angiology. 1991 Feb;42(2):123-32. doi: 10.1177/000331979104200206.

DOI:10.1177/000331979104200206

PMID:1706567

Abstract

Perivascular innervation in cerebral arteries of spontaneously hypertensive rats and of normotensive Wistar-Kyoto rats was studied. Adrenergic nerve fibers and neuropeptide Y-containing nerve fibers, indicative of vasoconstrictor nerves, were denser in all cerebral arteries of spontaneously hypertensive rats than those of Wistar-Kyoto rats. In contrast, cholinergic nerve fibers and vasoactive intestinal polypeptide, substance P-containing nerve fibers, indicative of vasodilator nerves, remained unchanged in all cerebral arteries of spontaneously hypertensive rats, as compared with findings in the Wistar-Kyoto rats. Thus, not only adrenergic nerve fibers but also neuropeptide Y-containing nerve fibers may play an important role in preventing the disruption of the blood-brain barrier and the development of hypertensive encephalopathy in spontaneously hypertensive rats.

摘要

对自发性高血压大鼠和正常血压的Wistar-Kyoto大鼠脑动脉的血管周围神经支配进行了研究。作为血管收缩神经指标的肾上腺素能神经纤维和含神经肽Y的神经纤维，在自发性高血压大鼠的所有脑动脉中比Wistar-Kyoto大鼠的更密集。相比之下，作为血管舒张神经指标的胆碱能神经纤维和含血管活性肠肽、P物质的神经纤维，与Wistar-Kyoto大鼠的结果相比，在自发性高血压大鼠的所有脑动脉中保持不变。因此，不仅肾上腺素能神经纤维，而且含神经肽Y的神经纤维可能在预防自发性高血压大鼠血脑屏障破坏和高血压脑病发展中起重要作用。