Eropkin M Iu, Solovskiĭ M V, Tikhomirova O M, Briazzhikova T S, Smirnova M Iu, Eropkina E M, Smirnova T S
Eksp Klin Farmakol. 2009 Sep-Oct;72(5):38-42.
A series of copolymers of acrylamide (Am) with 2-acrylamido-2-methylpropanesulfonic acid (AmMPSA) and N-2-hydroxypropyl-methacrylamide (HPMA) with acrylic acid (AA) have been synthesized. Complexes of gentamycin in the base form with these polymers and dextran sulfate were obtained. It is established that both poly(AmMPCA) and its complex with gentamycin exhibit an antiviral activity in vitro against human A(H3N2) influenza virus and herpes simplex virus of type 1 (HSV-1). The HPMA-AA copolymer and its complex with gentamycin are only active against HSV-1. Complexes of gentamycin with the polyanions based on the Am derivatives and dextran sulfate showed a high level of antibacterial activity against four bacterial strains. All the polymers studied as well as their complexes with gentamycin demonstrated a low toxicity in vitro, which makes them promising for the creation of preparations with combined antiviral and antimicrobial properties.
已合成了一系列丙烯酰胺（Am）与2-丙烯酰胺基-2-甲基丙烷磺酸（AmMPSA）的共聚物，以及N-2-羟丙基甲基丙烯酰胺（HPMA）与丙烯酸（AA）的共聚物。得到了庆大霉素碱形式与这些聚合物及硫酸葡聚糖的复合物。已确定聚（AmMPCA）及其与庆大霉素的复合物在体外对人A（H3N2）流感病毒和1型单纯疱疹病毒（HSV-1）均表现出抗病毒活性。HPMA-AA共聚物及其与庆大霉素的复合物仅对HSV-1有活性。庆大霉素与基于Am衍生物的聚阴离子及硫酸葡聚糖的复合物对四种细菌菌株表现出高水平的抗菌活性。所研究的所有聚合物及其与庆大霉素的复合物在体外均显示出低毒性，这使其有望用于制备具有抗病毒和抗菌联合特性的制剂。
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