Marchetti M, Pisani S, Pietropaolo V, Seganti L, Nicoletti R, Orsi N
Istituto Pasteur-Fondazione Cenci Bolognetti, Istituto di Microbiologia, Università La Sapienza, Roma, Italy.
J Chemother. 1995 Apr;7(2):90-6. doi: 10.1179/joc.1995.7.2.90.
Different natural and semisynthetic polysaccharides were evaluated for their inhibitory effect on in vitro replication of herpes simplex virus (HSV) types 1 and 2. Some neutral and negatively charged carbohydrates were able to inhibit viral infection by interfering mainly with the adsorption process showing a dose-dependent relationship. Their effect was shown within the concentration range of 200-0.8 micrograms/ml, and the inhibiting compounds were in order of action: dextran sulfate = scleroglucan = lambda carrageenan > glyloid sulfate 4324 > locust beam gum towards HSV-1 and dextran sulfate = glyloid sulfate 4324 = lambda carrageenan > scleroglucan > glycogen sulfate 4435 towards HSV-2. The data obtained indicate that the antiviral activity of polysaccharides was not only related to their electric charge. Other characteristics of the molecules such as the polymeric backbone, the carbohydrate moieties and the degree of polymerization could play a role in influencing their antiviral properties.
评估了不同的天然和半合成多糖对1型和2型单纯疱疹病毒（HSV）体外复制的抑制作用。一些中性和带负电荷的碳水化合物能够通过主要干扰吸附过程来抑制病毒感染，呈现出剂量依赖性关系。它们的作用在200 - 0.8微克/毫升的浓度范围内显现，抑制化合物的作用顺序为：对于HSV - 1，硫酸葡聚糖 = 硬葡聚糖 = λ-角叉菜胶 > 4324型硫酸甘聚糖 > 刺槐豆胶；对于HSV - 2，硫酸葡聚糖 = 4324型硫酸甘聚糖 = λ-角叉菜胶 > 硬葡聚糖 > 4435型硫酸糖原。所获得的数据表明，多糖的抗病毒活性不仅与其电荷有关。分子的其他特征，如聚合物主链、碳水化合物部分和聚合度，可能在影响其抗病毒特性方面发挥作用。
