Krupicka J, Janota T, Kasalová Z, Hradec J
Third Department of Internal Medicine, First School of Medicine and University General Hospital, Charles University in Prague, Czech Republic.
Physiol Res. 2010;59(4):625-628. doi: 10.33549/physiolres.931773. Epub 2009 Nov 20.
Many studies documented the relationship between elevated plasma concentrations of natriuretic peptides and cardiovascular diseases, especially heart failure. However, it is still uncertain whether physical exercise leads to a significant release of natriuretic peptide in healthy subjects. The aim of this study was to determine the effect of maximal physical activity on plasma BNP concentrations in healthy individuals within 3 hours after the short-term exercise. BNP plasma concentrations were measured in 15 healthy volunteers before, immediately after as well as 1 hour and 3 hours after bicycle spiroergometry. Maximal workload and exercise capacity were assessed in watts, watt-seconds, metabolic equivalents and VO(2max). Mean BNP plasma levels before, immediately after, 1 hour and 3 hours post-exercise were 19.4+/-2.5; 30.6+/-4.7; 17.9+/-2.5 and 18.7+/-3.1 pg/ml, respectively. The increase of BNP concentrations immediately after exercise was statistically significant (p=0.0017) compared to baseline values. We did not find any correlation between the post-exercise increase of BNP levels and age, body mass index, maximal workload or exercise capacity. In conclusion, short-term maximal physical exercise in healthy individuals led to a fast and transient rise of plasma BNP concentrations, which remained well within normal range and far below the cut-off value for heart failure (100 pg/ml).
许多研究记录了利钠肽血浆浓度升高与心血管疾病尤其是心力衰竭之间的关系。然而，体育锻炼是否会导致健康受试者体内利钠肽的显著释放仍不确定。本研究的目的是确定短期运动后3小时内最大体力活动对健康个体血浆脑钠肽（BNP）浓度的影响。在15名健康志愿者进行自行车运动心肺功能测试前、运动结束即刻、运动后1小时和3小时测量其血浆BNP浓度。通过瓦特、瓦特秒、代谢当量和最大摄氧量（VO₂max）评估最大工作量和运动能力。运动前、运动结束即刻、运动后1小时和3小时的平均血浆BNP水平分别为19.4±2.5、30.6±4.7、17.9±2.5和18.7±3.1 pg/ml。与基线值相比，运动结束后即刻BNP浓度的升高具有统计学意义（p = 0.0017）。我们未发现运动后BNP水平升高与年龄、体重指数、最大工作量或运动能力之间存在任何相关性。总之，健康个体进行短期最大体力运动导致血浆BNP浓度快速短暂升高，该浓度仍处于正常范围内且远低于心力衰竭的临界值（100 pg/ml）。
