Wartchow Eric P, Goin Luann, Schreiber Jillian, Mierau Gary W, Terella Adam, Allen Gregory C
Department of Pathology, The Children's Hospital, Aurora, Colorado 80045, USA.
Ultrastruct Pathol. 2009 Dec;33(6):286-92. doi: 10.3109/01913120903348860.
Plexiform fibrohistiocytic tumor is a low-grade soft tissue malignancy that can at times be difficult to differentiate from the less biologically aggressive cellular neurothekeoma. The two entities, which may display identical clinical and histological features, cannot be distinguished by immunohistochemical or molecular diagnostic means. Electron microscopy may enable the accurate identification of problematic examples and thus aid in resolving these occasionally occurring diagnostic dilemmas. To illustrate typical variations in the ultrastructural appearance of plexiform fibrohistiocytic tumor, the authors present two diagnostically noncontroversial examples, and to demonstrate the potential diagnostic utility of electron microscopy in this setting, they present an example of plexiform fibrohistiocytic tumor that could not otherwise have been distinguished from cellular neurothekeoma.
丛状纤维组织细胞瘤是一种低级别软组织恶性肿瘤，有时难以与生物学行为不太侵袭性的细胞性神经鞘瘤相鉴别。这两种实体可能表现出相同的临床和组织学特征，无法通过免疫组化或分子诊断方法区分。电子显微镜检查可能有助于准确识别疑难病例，从而有助于解决这些偶尔出现的诊断难题。为了说明丛状纤维组织细胞瘤超微结构外观的典型变化，作者展示了两个诊断上无争议的病例，并为了证明电子显微镜检查在这种情况下的潜在诊断效用，展示了一个无法与细胞性神经鞘瘤相鉴别的丛状纤维组织细胞瘤病例。
