Topsakal Ramazan, Kalay Nihat, Gunturk Ertugrul Emre, Dogan Ali, Inanc Mehmet Tugrul, Kaya Mehmet Gungor, Ergin Ali, Yarlioglues Mikail
Department of Cardiology, Erciyes University Medicine Faculty, Kayseri, Turkey.
Blood Press. 2009;18(6):367-71. doi: 10.3109/08037050903350788.
The serotonin levels in thrombocytes are decreased in hypertensive patients. The aim of our study was to investigate the relationship between serotonin levels and insufficient nocturnal blood pressure (BP) decrease (non-dipper) in hypertensive patients.
Fifty-six hypertensive patients and 27 healthy control subjects were included in the study. Of the hypertensive patients, 28 were classified as dippers and 28 as non-dippers based on nocturnal BP drops of >10 mmHg and <10 mmHg, respectively. Thrombocyte serotonin levels, serum uric acid, and C-reactive protein (CRP), and urinary albumin/creatinine ratios were analysed. Thrombocyte serotonin levels were measured using an enzyme immunoassay.
The thrombocyte serotonin level was 378.9 +/- 69.5 ng/10(9) platelet in the non-dipper group, 424.7 +/- 58.6 ng/10(9) platelet in the dipper group, and 518.1 +/- 35.9 ng/10(9) platelet in the control group. Serotonin levels in the non-dipper group were significantly lower than in the dipper group. Serotonin levels negatively correlated with blood pressure (r = -0.6, p<0.001). CRP concentration in the non-dipper group was higher than in the dipper (4.8 +/- 1.4 vs 3.6 +/- 1.6, p<0.01) and control (2.4 +/- 0.9, p<0.001) groups, and microalbuminuria was significantly higher in the non-dipper group compared with dipper (24.9 +/- 8.6 vs 13.4 +/- 8.8, p<0.001) and control (9.6 +/- 4.8, p<0.001) groups. Serotonin level was negatively correlated with microalbuminuria (p<0.001, r = -0.3), uric acid (p<0.01, r = -0.3), and CRP (p<0.01, r = -0.35).
In non-dipper hypertensive patients, thrombocyte serotonin levels were significantly lower than in dipper and control groups. Serotonin levels may be related to insufficient nocturnal blood pressure decrease in hypertensive patients.
高血压患者血小板中的血清素水平降低。我们研究的目的是调查高血压患者血清素水平与夜间血压下降不足（非勺型）之间的关系。
本研究纳入了56例高血压患者和27例健康对照者。在高血压患者中，根据夜间血压下降幅度分别>10 mmHg和<10 mmHg，将28例分类为勺型，28例分类为非勺型。分析了血小板血清素水平、血清尿酸、C反应蛋白（CRP）以及尿白蛋白/肌酐比值。采用酶免疫测定法测量血小板血清素水平。
非勺型组血小板血清素水平为378.9±69.5 ng/10⁹血小板，勺型组为424.7±58.6 ng/10⁹血小板，对照组为518.1±35.9 ng/10⁹血小板。非勺型组的血清素水平显著低于勺型组。血清素水平与血压呈负相关（r = -0.6，p<0.001）。非勺型组的CRP浓度高于勺型组（4.8±1.4 vs 3.6±1.6，p<0.01）和对照组（2.4±0.9，p<0.001），非勺型组的微量白蛋白尿显著高于勺型组（24.9±8.6 vs 13.4±8.8，p<0.001）和对照组（9.6±4.8，p<0.001）。血清素水平与微量白蛋白尿（p<0.001，r = -0.3）、尿酸（p<0.01，r = -0.3）和CRP（p<0.01，r = -0.35）呈负相关。
在非勺型高血压患者中，血小板血清素水平显著低于勺型组和对照组。血清素水平可能与高血压患者夜间血压下降不足有关。
