Swartz Karin R, Scheff Nicole N, Roberts Kelly N, Fee Dominic B
Department of Neurosurgery, University of Kentucky, Lexington, KY 40536-0298, USA.
J Neurosurg Spine. 2009 Nov;11(5):570-4. doi: 10.3171/2009.5.SPINE08588.
The authors used a rat model to assess spinal cord compression following an incomplete spinal cord injury (SCI).
Incomplete SCI was created in the thoracic spinal cord in a novel application of a rodent spinal cord compression model. A moderate impaction force was applied instantaneously to the spinal cord and was followed by 0 seconds, 10 seconds, 30 seconds, or 5 minutes of continued compression (termed "dwell"). The different groups were assessed by behavioral testing with the Basso, Beattie, Bresnahan locomotor rating scale, and with histological injury quantification and morphometrical analysis.
Compression after the SCI resulted in worsened Basso, Beattie, Bresnahan scale scores; however, the duration of compression was not significant. Compression did not significantly affect the percentage of spared total tissue, percent spared total white matter, or percent spared total gray matter. Percent spared tissue at the epicenter of injury was statistically worsened by compression but not in a time-dependent manner.
The authors' results suggest that spinal cord compression after the initial injury is an additional mechanism by which SCI worsens, and that the mechanism of this injury occurs rapidly. These data, however, do not support duration of compression as a significant variable.
作者使用大鼠模型评估不完全性脊髓损伤（SCI）后的脊髓压迫情况。
在一种新型的啮齿动物脊髓压迫模型中，在胸段脊髓造成不完全性SCI。对脊髓瞬间施加适度撞击力，随后持续压迫0秒、10秒、30秒或5分钟（称为“停留”）。通过使用Basso、Beattie、Bresnahan运动评分量表进行行为测试，以及组织学损伤定量和形态计量分析对不同组进行评估。
SCI后进行压迫导致Basso、Beattie、Bresnahan量表评分恶化；然而，压迫持续时间并无显著影响。压迫对 spared 总组织百分比、 spared 总白质百分比或 spared 总灰质百分比无显著影响。损伤中心处的 spared 组织百分比在统计学上因压迫而恶化，但并非呈时间依赖性。
作者的结果表明，初始损伤后的脊髓压迫是SCI恶化的另一种机制，且这种损伤机制发生迅速。然而，这些数据并不支持压迫持续时间作为一个显著变量。
