Budunova I V, Vaĭnberg R M
Biull Eksp Biol Med. 1977 Sep;84(9):346-9.
Both the cells of monolayer culture of mouse embryonic liver and that of highly malignant hepatoma 22A transplanted for 20 years actively metabolized the carcinogenic hydrocarbon benz(a)pyrene and were highly sensitive to iits toxic action. Since hepatic tissue was resistant in vivo to carcinogenic carbohydrates it is suggested that the resistance depended on factors acting at the organ or the organism but not as the cellular level. The mechanism of retention of hepatoma 22A sensitivity to the toxic action of benz(a)pyrene is also discussed.
小鼠胚胎肝单层培养细胞和移植20年的高恶性肝癌22A细胞均能积极代谢致癌烃苯并(a)芘，且对其毒性作用高度敏感。由于肝组织在体内对致癌碳水化合物具有抗性，因此表明这种抗性取决于作用于器官或机体的因素，而非细胞水平的因素。本文还讨论了肝癌22A对苯并(a)芘毒性作用保持敏感的机制。
