Beliaeva I D, Ivleva T S
Biull Eksp Biol Med. 1977 Feb;83(2):218-20.
A study was made of the progress rate of cells of the ascitic hepatoma 22A of different age during the iirst mitotic cycle after the stimulation of division. The "ageing" (11-day), terminal (14-day), and "delayed" (4 days older than the terminal stage) ascitic fluids were used. The maximal values of the labeled nuclei index was found to be reached by 9--12 hours (it was mainly due to the transtion of the quiescent to the S-period) and the maximal mitotic index--by 18--21 hours after the inoculation, independently of the tumour age. These results suggest that the duration of both the prereplicative (G1) period and of the whole first mitotic cycle after the stimulation were independent of the time during which the cells of the ascitic hepatoma 22A were at the resting stage or at the very prolonged G1-period.
对不同年龄的腹水型肝癌22A细胞在分裂刺激后的第一个有丝分裂周期中的进展速率进行了研究。使用了“衰老”（11天）、终末期（14天）和“延迟”（比终末期大4天）的腹水。发现标记核指数的最大值在接种后9 - 12小时达到（这主要是由于静止期细胞向S期的转变），最大有丝分裂指数在接种后18 - 21小时达到，与肿瘤年龄无关。这些结果表明，复制前期（G1）期和刺激后整个第一个有丝分裂周期的持续时间与腹水型肝癌22A细胞处于静止期或非常长的G1期的时间无关。
