Gelbaya Tarek A
Assisted Conception Unit, Kensington Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK.
Hum Fertil (Camb). 2010 Mar;13(1):19-27. doi: 10.3109/14647270903437923.
There are a number of potential risks to women who conceive through in vitro fertilisation (IVF). Among these, ovarian hyperstimulation syndrome and multiple pregnancies are the most serious. Other potential risks include increased levels of anxiety and depression, ovarian torsion, ectopic pregnancy, pre-eclampsia, placenta praevia, placental separation and increased risk of cesarean section. The association between assisted conception and long-term risk of cancer is debatable. The objective of this review is to critically evaluate the current evidence for potential risks to women who conceive through IVF. To assess the relative risk for any condition, a number of factors need to be taken into account including the method used in identifying the study and control group, the women's characteristics and the number of women included in the study. Many conditions such as ectopic pregnancy and pre-eclampsia appear to be commoner in assisted conception than in spontaneous pregnancy. Nevertheless, the increased risk of these conditions is probably related to the woman's subfertility status and/or increased incidence of multiple pregnancy. Currently, all efforts should concentrate on reduction of multiple births from IVF by restricting the number of transferred embryos.
通过体外受精（IVF）受孕的女性存在多种潜在风险。其中，卵巢过度刺激综合征和多胎妊娠最为严重。其他潜在风险包括焦虑和抑郁水平升高、卵巢扭转、宫外孕、先兆子痫、前置胎盘、胎盘早剥以及剖宫产风险增加。辅助生殖与癌症长期风险之间的关联存在争议。本综述的目的是严格评估目前关于通过IVF受孕的女性潜在风险的证据。为评估任何疾病的相对风险，需要考虑多个因素，包括识别研究组和对照组所使用的方法、女性的特征以及研究中纳入的女性数量。许多疾病，如宫外孕和先兆子痫，在辅助生殖中似乎比自然受孕更为常见。然而，这些疾病风险的增加可能与女性的不孕状态和/或多胎妊娠发生率增加有关。目前，所有努力都应集中在通过限制移植胚胎数量来减少IVF导致的多胎分娩。
