Yuk Jin-Sung, Shin Ji-Yeon, Park Won I, Kim Dae Woon, Shin Jung Whan, Lee Jung Hun
Department of Obstetrics and Gynaecology, School of Medicine, Eulji University, Daejeon Department of Obstetrics and Gynaecology, MizMedi Hospital, Seoul Department of Preventive Medicine, School of Medicine, Eulji University, Daejeon, Korea Department of Obstetrics and Gynecology, Hankang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea Department of Obstetrics and Gynecology, Gyeongsang National University Changwon Hospital, Gyeongsang National University, School of Medicine, Changwon, Republic of Korea.
Medicine (Baltimore). 2016 Jun;95(24):e3861. doi: 10.1097/MD.0000000000003861.
The purpose of this study was to determine the effect of pregnancy on adnexal torsion (AT). We conducted a matched case-control study using the Korean Health Insurance Review and Assessment Service-National Inpatients Sample (HIRA-NIS) from 2009 to 2011. AT patients were defined as women with both a diagnostic code (N835) and a surgical code for AT. The AT patients were randomly matched 1:4 with women without AT by age and year of claim. In total, 545 AT cases and 2180 controls were enrolled from a total of 1,843,451 women. After adjustment for such covariates as age, pregnancy was found to be associated with a lower rate of AT (adjusted odds ratio 0.314, 95% confidence interval [CI] 0.237-0.416, P value <0.01) and ovarian hyperstimulation syndrome was associated with a higher rate of AT (adjusted odds ratio 20.091, 95% CI 3.607-111.908, P value <0.01). We found that pregnancy is a negative risk factor for AT. However, a further study is needed to elucidate the mechanisms underlying these results.
本研究的目的是确定妊娠对附件扭转（AT）的影响。我们利用2009年至2011年韩国健康保险审查与评估服务中心-全国住院患者样本（HIRA-NIS）进行了一项匹配病例对照研究。AT患者定义为具有诊断代码（N835）和AT手术代码的女性。AT患者按年龄和索赔年份与无AT的女性以1:4的比例随机匹配。总共从1,843,451名女性中纳入了545例AT病例和2,180名对照。在对年龄等协变量进行调整后，发现妊娠与较低的AT发生率相关（调整后的优势比为0.314，95%置信区间[CI]为0.237 - 0.416，P值<0.01），而卵巢过度刺激综合征与较高的AT发生率相关（调整后的优势比为20.091，95%CI为3.607 - 111.908，P值<0.01）。我们发现妊娠是AT的一个负性危险因素。然而，需要进一步研究以阐明这些结果背后的机制。
